Synthesis of New Diaryl Ethers with Anti-Enteroviral Activity

Abstract from Fourth National Congress of Virology with International Participation /Days of Virology in Bulgaria Sofia, May 18th - 20th, 2016

Georgi M. Dobrikov

Institute of Organic Chemistry with Centre of Phytochemistry, Bulgarian Academy of Sciences, Sofia, Bulgaria

The synthesis of a series of more than 60 new diaryl ether compounds was accomplished starting from 2-chloro-5-nitrobenzonitrile and different phenols. The reactions were carried out under basic conditions (NaOH or KOH) in DMSO. Most of the compounds are near analogues of DNB – well known active compound against enteroviruses.

All compounds were obtained in high yields and purity after column chromatography and were characterized by NMR, MS-spectra, melting points and elemental analysis.

The new synthesized diarylethers were tested for their anti-enteroviral activity.