Synthesis of New Diaryl Ethers with Anti-Enteroviral Activity
Abstract from Fourth National Congress of Virology with International Participation /Days of Virology in Bulgaria Sofia, May 18th - 20th, 2016
Georgi M. Dobrikov
Institute of Organic
Chemistry with Centre of Phytochemistry, Bulgarian Academy of Sciences, Sofia,
The synthesis of a series of more than 60 new diaryl ether
compounds was accomplished starting from 2-chloro-5-nitrobenzonitrile and different
phenols. The reactions were carried out under basic conditions (NaOH or KOH) in
DMSO. Most of the compounds are near analogues of DNB – well known active
compound against enteroviruses.
All compounds were obtained in high yields and purity after
column chromatography and were characterized by NMR, MS-spectra, melting points
and elemental analysis.
The new synthesized diarylethers were tested for their