Seroprevalence to Cytomegalovirus in the Bulgarian Population, 2003-2015
Zhivka Stoykova, Liliya Iv. Ivanova
Department of Microbiology and Virology, Faculty of Medicine, Medical University, Varna, Bulgaria
Laboratory of Clinical Virology, St. Marina University Hospital, Varna, Bulgaria
The prevalence of cytomegalovirus (CMV) infections is between 50% and 85% in adults in different parts of the world. Its epidemiology varies between socioeconomic and age groups. Our retrospective study has been performed to determine the seroprevalence of CMV in the general population in Northeastern Bulgaria. Between 2003 – 2015, we estimated the prevalence of individuals with antibodies to CMV using indirect enzyme-linked immunosorbent assay to detect virus-specific IgG and IgM. The population sample included 7879 individuals of both sexes and different ages. The total seroprevalence of CMV was determined as 78.4%.
The relative deal of acute CMV infections was determined as 22.8%. We analysed the proportion of CMV IgG and IgM by sex and/or age group. The results of the study reveal that CMV infection is highly prevalent in the population and occurs mainly in the first years of life.