Seroprevalence of EBV Infection in North-East Bulgaria

Abstract from Fourth National Congress of Virology with International Participation /Days of Virology in Bulgaria Sofia, May 18th - 20th, 2016

Tsvetelina Kostadinova, Liliya Ivanova, Todor Raykov, Zhivka Stoikova, Gabriela Tsankova

Education and Research Sectors of Medical laboratory assistant, Medical Colleage, Medical University, Varna.

Department of Microbiology and Virology, Faculty of Medicine, Medical University, Varna.

Association of patients with rheumatoid arthritis.

Department of Preclinical and Clinical Sciences, Faculty of Pharmacy, Medical University, Varna.


Background: EBV is the first human oncogenic virus which is associated with Burkit’s lymphoma, spread in Africa, and NPC, mostly in South China. During the primary infection, especially if it appears during adolescent and shortly after, IM clinic is developed. Several researches have established that people, that have had clinically developed IM, have roughly three times higher risk of developing Hodgkins’ lymphoma. The highest risk is during the first 3 years after the EBVinfection, however the interval could be between six months and twenty years. EBV is widely spread member of the Herpesviridae family. Data shows that in more than 90% of the adults’ population of the world specific anti-VCA IgG can be found. In different researches from Bulgaria the seroprevalence is between 60% and 80%.

The goal of this study is to establish the frequency of EBV amongst the population of Northeast Bulgaria.


1. To research the seroepidemiological status of the population in Northeast Bulgaria.

2. To analyse the frequency of the laboratory confirmed IM.

Materials and methods: 5016 serum samples of people tested for numerous reasons for EBV have been analysed for the period 2010-2015. People of age between 1month and 70+ years are split into sixteen age groups. 625 of them have been diagnosed with IM. The samples have been tested using the ELISA method for detection of anti VCA, IgM and IgG.

Conclusion: High frequency of EBV amongst the population of Northeast Bulgaria is expected.

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