Abstract from Fourth National Congress of Virology with International Participation /Days of Virology in Bulgaria Sofia, May 18th - 20th, 2016
National Centre of
Infectious and Parasitic Diseases
There was published report in the 19th century that in
children suffering from leukemia a measles infection improved their cоndition.
But this fact didnnot impress healers and researchers. It was not until the end
of the 20 th century, with the increased knowledge of tumors and viruses that
the idea of using the latter for treatment of cancer attracted the attention of
scientists. Since the beginning of the present century there has been an
avalanche of publications on testing the impact of viruses on tumors.
As a research subject scientists have used cell cultures and
transgenic mices implanted with different types of human tumors, which are
being targeted successfully by viruses. And, finally, this has been applied in
This article examines in more detail the research conducted
by a team in Mayo clinic in Rochester, USA, on the effect of the vaccine
measles virus on Multiple Мyeloma. In its work, the team formulates the basic
requirements for viral treatment : safety for healthy cell; clarifying of the
mechanisms of penetration, reproduction and destructive action of the virus on
cancer cells. The obtained results, which have been conformed by other teams,
laid the beginning of a new medical specialty, oncolytic virusоtherapy.